Cytokine receptors IFNγR1, IL10Rα and IFNαR1/2 cis-dimers significantly enhance the binding of relevant cytokines

Poster Abstract Cytokines initiate signaling on target cells by engaging the ectodomains (ECDs) of cell surface receptors. Cytokine receptor dimeric forms are critical for cytokine ligand binding. To mimic the dimeric receptor conformation, we engineered novel cishomodimers for human Type II interferon IFNγ receptor 1 (IFNγR1) and interleukin 10 receptor alpha (IL10Rα), and the cis-heterodimer […]