Bioactive, Soluble, Conformational Target Proteins
Cytokine Receptors, Immune Checkpoint Receptors, Growth Factor Receptors, Tumor Associated Antigens, T cells Receptors and Coreceptors
Direct detection for biologics and gene therapy, including CAR-T, Multi Specific, and ADC.
High Target Density Virus-Like Particles
G Protein-Coupled Receptors (GPCRs), Claudin Family Proteins, Ion Channels
High sensitivity detection of receptor/ligand binding interactions.
Monoclonal Antibodies for GPCR Targets
Immune & Inflammation, Neurology, Cardiovascular, Metabolic, Oncology
Binding GPCR targets for live-cell staining by flow cytometry.
CD19 Fc-free homodimer shows strong binding to FDA approved therapeutic antibodies by ELISA.
Can Detect the Target Expressed on Live Cell Surfaces by Flow Cytometry
Human TROP-2 is a cell-surface transmembrane type-1 glycoprotein expressed in epithelial cells of various tissues.
New Conformational Proteins & Antibodies
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- Fit-for-target immunogen sequence design
- Proprietary molecular adjuvant formulation
- Immune-focusing based immunization regimen
Technology Platforms for Novel Recombinant Conformational Proteins
Conigen Soluble Proteins (CSP™) & Conigen Membrane Proteins (CMP™)
CSP vs cell-based assays for bioactivity
- No need for developing corresponding cell line for every target
- CSP can preserve the native conformations similar to those on cell surfaces
- Easy to scale-up and develop high-through-put assays
CSP vs whole cell immunization
- No host cell proteins
- Dramatically higher number of molecules for each immunization
- Highly immunogenic
- Preserves the native conformations similar to those on cell surfaces
CSP vs monomeric proteins of extracellular domains for bioactivity measurement
- CSP not limited to monomeric proteins without critical conformational epitopes on the quaternary structures
- Provides better conformational epitopes for antibody screening and affinity evaluation
- Enhances assay sensitivity and potency; generates wider windows for agonist and antagonist activity evaluation
- Better conformation for antibody/antigen, receptor/ligand complex structural analysis
CMP vs reconstituted membrane-lipid-belt protein formats (Nanodiscs, liposomes)
- More natively folded proteins in the cellular membrane bilayer without further processing
CMP vs peptides immunization
- Eliciting antibodies that better target conformational epitopes
CMP vs whole cell immunization
- Higher antigen dosage per immunization
- Reduced number of host cell derived proteins
- More immunogenic