Multimeric Conformational Proteins | High Ligand Binding Potency | Large Assay Window
Soluble Proteins
Single-pass ectodomain dimers
✔ Cytokine Receptors
✔ Immune Checkpoint Receptors
✔ Tumor Associated Antigens
✔ Growth Factor Receptors
Membrane-Associated Proteins
Full length multi-pass
✔ G Protein-Coupled Receptors
✔ Claudin Family Proteins
✔ Ion Channels
Custom Protein Expression
✔ Dimeric Soluble Proteins
✔ Virus-Like Particles
✔ Recombinant Antibodies
Discover how native-like protein dimers improve assay potency
Recombinant Cytokine Receptors with Potent Binding Affinities
New Conformational Proteins
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Technology Platforms for Novel Recombinant Conformational Proteins
Conigen Soluble Proteins (CSP™) & Conigen Membrane Proteins (CMP™)
CSP vs cell-based assays for bioactivity
- No need for developing corresponding cell line for every target
- CSP can preserve the native conformations similar to those on cell surfaces
- Easy to scale-up and develop high-through-put assays
CSP vs whole cell immunization
- No host cell proteins
- Dramatically higher number of molecules for each immunization
- Highly immunogenic
- Preserves the native conformations similar to those on cell surfaces
CSP vs monomeric proteins of extracellular domains for bioactivity measurement
- CSP not limited to monomeric proteins without critical conformational epitopes on the quaternary structures
- Provides better conformational epitopes for antibody screening and affinity evaluation
- Enhances assay sensitivity and potency; generates wider windows for agonist and antagonist activity evaluation
- Better conformation for antibody/antigen, receptor/ligand complex structural analysis
CMP vs reconstituted membrane-lipid-belt protein formats (Nanodiscs, liposomes)
- More natively folded proteins in the cellular membrane bilayer without further processing
CMP vs peptides immunization
- Eliciting antibodies that better target conformational epitopes
CMP vs whole cell immunization
- Higher antigen dosage per immunization
- Reduced number of host cell derived proteins
- More immunogenic