Immobilized human LPAR1 at 2 μg/mL (100 μL/well) can bind anti-human LPAR1 monoclonal antibody (Cat. No. CABh-24026) with half maximal effective concentration (EC50) range of 0.1-0.5 μg/mL (QC tested).
Anti-Human LPAR1 Monoclonal Antibody
Antibody
Product Code: CABh-24026
Isotype: IgG2a, kappa
Conjugate: Unconjugated
Specificity: Human lysophosphatidic acid receptor 1/LPAR1
Host Species: Mouse
Immunogen: LPAR1 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # Q92633
Purification: Affinity Enrichment
Verified Applications: ELISA, SPR
Purity: >90% as determined by SDS-PAGE under non-reducing condition
Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Regulation of cell proliferation, migration, survival, apoptosis, and morphology
Ligand/Receptor: lysophosphatidic acid (LPA)
Cell Type: Central nervous system cells
Molecular Family: G protein-coupled receptor
Gene ID: Q92633
Product Name: Anti-huLPAR1
Predicted Molecular Weight: N/A
Protein Construct: N/A
Background and Alternate Names
Human lysophosphatidic acid receptor 1 (LPAR1) is a Class A G protein-coupled receptor (GPCR) with seven transmembrane helices on the cell surface. LAPR1 is found in almost all human tissues but is the most highly expressed in the brain. It is involved in reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, as well as contributing to the responses to tissue damage and infectious agents, neuroblastoma cell differentiation inhibition, chemotaxis, and tumor cell invasion. Deletion of the LPAR1 gene causes neurodevelopmental disorders and central nervous system diseases such as brain cancer, and neuropsychiatric disorders. Human LPAR1 protein has ~99% and ~97% sequence homology with macaque and mouse LPAR1, respectively.
Immobilized human LPAR1 at 2 μg/mL (100 μL/well) can bind anti-human LPAR1 monoclonal antibody (Cat. No. CABh-24026) with half maximal effective concentration (EC50) range of 0.1-0.5 μg/mL (QC tested).
