Custom Recombinant Proteins & Antibodies
Custom Protein Expression & Antibody Production Services | Native-like Bioactivity for Drug Discovery
Structure isn’t just a feature — it’s the foundation of function.
Conigen provides custom recombinant protein and antibody production services for drug discovery, immune profiling, and functional screening. Our platforms are designed to preserve native-like structure and activity, enabling more reliable results in discovery, development, and screening workflows.
We apply standardized procedures across each phase of the project — from construct design to data-backed delivery — to support consistent output and scalable collaboration.
Our Workflow
Transparent. Modular. Built for reproducibility.
Each project follows a stepwise, milestone-driven workflow with built-in decision points and reporting at every stage. Clients receive detailed technical documentation and data packages for downstream application and analysis.
Custom Recombinant Conformational Protein Expression
The CSP™ (Conigen Soluble Protein) technology platform is used to produce soluble recombinant dimeric proteins with a quaternary structure mimicking the native conformation of protein complexes on cell surfaces, such as receptors or cancer target proteins.
The CMP™ (Conigen Membrane Protein) nanoparticle technology platform is used to produce native conformational membrane proteins by using the self-assembling and then budding functions of the viral core proteins.
Use cases: Binding assays, antibody discovery, structural validation, vaccine research
Deliverables: Milligram-scale protein, expression and QC data report
Recombinant Antibody Expression in Mammalian Cells
We express recombinant antibody heavy and light chains in mammalian cells for early-stage validation and screening. Ideal for rapid evaluation of binder function and specificity.
Use cases: Screening, reagent validation, assay development
Deliverables: Antibody (milligram scale), expression and purity data
Mouse Monoclonal Antibody Development
We offer custom hybridoma development services tailored to structurally complex antigens, including membrane proteins and low-immunogenicity targets.
Use cases: Monoclonal antibody generation, tool antibody programs
Deliverables: Hybridoma clones, purified antibody, characterization data
Why Work With Conigen
- Our CSP™ and CMP™ platforms support expression of structurally complex dimeric and membrane proteins
- Experience with >150 challenging protein targets
- Purpose-built strategies for membrane and multimeric proteins
- Emphasis on structural fidelity and biological function
- Full project transparency, QC checkpoints, and data reporting
FAQs
How much purified protein will I receive?
In general, 1-10 mg of protein can be provided upon request.
Can I request a specific method to verify and quantify the expression of my protein variants?
Yes
Do you offer mutations other than single amino acid substitutions?
Yes, it will be based on specific request.
Can I request expression of more than one protein at a time?
Yes
What other conjugation tags are available, apart from HIS on the Fc domain?
Yes, Avitag, Biotin, Flag tag, HA tag, and Myc tag are also available in addition to His and Fc tags
What cell lines do you use for protein expression? Can I request a specific cell line?
HEK293 and CHO cell lines are commonly used. A specific cell can be used per request.
What information is included on the datasheet for these custom proteins?
Protein sequence information, purity, concentration, amount, other information upon request for each specific protein.
Do you offer assay development or other specialized R&D work?
Yes
What happens if you run into technical difficulties with my target protein and cannot complete the project?
If technical difficulties are encountered, we will inform the customer, troubleshoot, discuss with the customer and find the specific solution.