Immobilized human NPR3 fragment at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human NPR3 Monoclonal Antibody (Cat. No. CABh-25373) with half maximal effective concentration (EC50) range of 6.2-24.8 ng/mL (QC tested).
Immobilized human NPR3 peptide can bind Mouse Anti-Human NPR3 Monoclonal Antibody (Cat. No. CABh-25373) with a KD of 0.5-2 nM as determined by LSPR (Nicoya Alto).

Anti-Human NPR3 Monoclonal Antibody

Product Category: Antibody

Product Code: CABh-25373
Isotype: IgG1
Conjugate: Unconjugated
Specificity: Human atrial natriuretic peptide receptor 3/NPR3
Host Species: Mouse
Immunogen: NPR3 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # P17342
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA, SPR
Recommended Usage: ELISA: starting concentration 1 µg/mL. LSPR: Recommended maximum concentration, 100 nM.

For Research Use Only (RUO)

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Formulation: 0.22μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: maintenance of blood pressure and extracellular fluid volume
Ligand/Receptor: osteocrin
Cell Type: High expression in kidney tissues with variable expression in other tissues such as the brain, heart, and gut.
Molecular Family: G protein-coupled receptor
Gene ID: P17342
Product Name: Anti-huNPR3
UniProt #: P17342
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human atrial natriuretic peptide receptor 3 (NPR3), is also called natriuretic peptide receptor C/guanylate cyclase C, atrionatriuretic peptide receptor C, C5orf23, GUCY2B, and BOMOS. NPR3 is highly expressed in kidney tissues. Binding of NPR3 to osteocrin is involved in maintenance of blood pressure and extracellular fluid volume. The interaction of NPR3 and osteocrin is a recent focus of possible therapeutics to treat diseases such as congestive heart failure. Human NPR3 protein has ~99% and ~91% sequence homology with macaque and mouse NPR3, respectively.

Alternate Names: Natriuretic peptide receptor C/guanylate cyclase C, atrionatriuretic peptide receptor C, ANP-C, ANPR-C, ANPRC, C5orf23, GUCY2B, NPR-C, NPRC, BOMOS