Immobilized human NPR3 peptide can bind Mouse Anti-Human NPR3 Monoclonal Antibody (Cat. No. CABh-25373) with a KD of 0.5-2 nM as determined by LSPR (Nicoya Alto).
Anti-Human NPR3 Monoclonal Antibody
Antibody
Product Code: CABh-25373
Isotype: IgG1
Conjugate: Unconjugated
Specificity: Human atrial natriuretic peptide receptor 3/NPR3
Host Species: Mouse
Immunogen: NPR3 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # P17342
Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: maintenance of blood pressure and extracellular fluid volume
Ligand/Receptor: osteocrin
Cell Type: High expression in kidney tissues with variable expression in other tissues such as the brain, heart, and gut.
Molecular Family: G protein-coupled receptor
Gene ID: P17342
Product Name: Anti-huNPR3
Human atrial natriuretic peptide receptor 3 (NPR3), is also called natriuretic peptide receptor C/guanylate cyclase C, atrionatriuretic peptide receptor C, C5orf23, GUCY2B, and BOMOS. NPR3 is highly expressed in kidney tissues. Binding of NPR3 to osteocrin is involved in maintenance of blood pressure and extracellular fluid volume. The interaction of NPR3 and osteocrin is a recent focus of possible therapeutics to treat diseases such as congestive heart failure. Human NPR3 protein has ~99% and ~91% sequence homology with macaque and mouse NPR3, respectively.
Immobilized human NPR3 peptide can bind Mouse Anti-Human NPR3 Monoclonal Antibody (Cat. No. CABh-25373) with a KD of 0.5-2 nM as determined by LSPR (Nicoya Alto).