Immobilized human GPR142 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human GPR142 Monoclonal Antibody (Cat. No. CABh-25372) with half maximal effective concentration (EC50) range of 5.7-22.6 ng/mL (QC tested).
Anti-Human GPR142 Monoclonal Antibody
Product Category: All Products
Product Code: CABh-25372
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: GPR142 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # Q7Z601
Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Appears to contribute to the control of glucose homeostasis by controlling the secretion of both insulin in the pancreas and other gastrointestinal hormones including glucagon
Ligand/Receptor: Unknown
Cell Type: Pancreatic islet and gastrointestinal enteroendocrine cells
Molecular Family: G protein-coupled receptor
Gene ID: Q7Z601
Product Name: GPR142, Monoclonal Antibody
UniProt #: Q7Z601
Predicted Molecular Weight: N/A
Protein Construct: N/A
Background and Alternate Names
Human G protein-coupled receptor 142, is a 7-transmembrane G protein-coupled receptor (GPCR) and member of the rhodopsin family. GPR142 is a Class A GPCR, primarily expressed in pancreatic islet β cells and gastrointestinal enteroendocrine cells. It functions as a nutrient sensor for aromatic amino acids such as tryptophan and phenylalanine is a tryptophan-activated Gαq-coupled receptor with enriched expression in pancreatic islets. GPR142 therapeutics are an active area of research, mainly focused on type 2 diabetes and metabolic disease, because of the receptor’s role in enhancing glucose-dependent insulin and incretin secretion.. Human GPR142 protein has ~85% sequence homology with mouse GPR142.
Immobilized human GPR142 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human GPR142 Monoclonal Antibody (Cat. No. CABh-25372) with half maximal effective concentration (EC50) range of 5.7-22.6 ng/mL (QC tested).