Innovative Precision Antibody Discovery Platform Generated GPCR-Specific Antibodies Binding to The Target on Live Cell Surfaces for A Panel of GPCRs

G protein-coupled receptors (GPCRs) regulate nearly every aspect of human physiology and diseases, and form one of the largest drug target families. GPCRs share a conserved structure with 7 transmembrane α-helices. Antibodies binding to a GPCR protein on the cell surface can be a very useful tool for target detection and potential drug discovery. The structure complexity and dynamic conformations make it very challenging to develop antibodies binding GPCRs on live cell surfaces. To advance GPCR antibody discovery, we have developed an innovative fit-for-target precision antibody discovery platform to generate GPCR-specific monoclonal antibodies (mAbs).