Immobilized human IFNαR2 monomer at 2 μg/mL (100 μL/well) can bind mouse Anti-Human IFNαR2 Monoclonal Antibody (Cat. No. CABh-24025.2) with half maximal effective concentration (EC50) range of 17.7-70.8 ng/mL (QC tested).,Immobilized human IFNαR1/R2 heterodimer (Cat. No. CSP-24025-A1B1) at 2 μg/mL (100 μL/well) can bind mouse Anti-Human IFNαR2 Monoclonal Antibody (Cat. No. CABh-24025.2) with half maximal effective concentration (EC50) range of 5.2-20.8 ng/mL (QC tested).

Anti-Human IFN alpha-R2 Monoclonal Antibody

Product Code: CABh-24025.2
Isotype: IgG2b
Specificity: Human
Host Species: Mouse
Immunogen: IFNαR2 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # P48551
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as protectant
Shipping: Frozen Ice Packs
Storage: -20’C

Datasheet

MSDS

Structure: IFNαR2 contains an N-terminal ligand binding domain containing two fibronectin type II-like subdomains, a transmembrane domain, and a cytoplasmic domain.
Function: Activates the JAK-STAT, MAPK, PI3K, and Akt signaling pathways
Ligand/Receptor: Type I IFNs
Cell Type: Nearly ubiquitous expression on all cell types but enhanced expression on peripheral blood B cells and monocytes
Molecular Family: Cytokine receptor
Gene ID: P48551
Product Name: IFNα-R2, Monoclonal Antibody
Human interferon-alpha/beta receptor subunit 2 (IFNαR2) is a subunit of the interferon-alpha/beta receptor (IFNαR1/R2) heterodimer cell surface receptor complex. IFNαR1/R2 is a Type 1 Interferon Receptor, primarily located on the cell plasma membrane and is composed of two subunits IFNαR1 and IFNαR2. IFNαR1/R2 recognizes type I interferon (IFN) cytokines such as IFN-α, IFN-β and others. Upon binding to type I IFNs, IFNαR1/R2 activates the JAK-STAT, MAPK, PI3K, and Akt signaling pathways. As Type 1 interferon signaling plays important roles in immune responses, dysregulation of IFNαR1/R2 activated pathways has been associated with various diseases, such as neurodegenerative diseases, autoimmune disorders and cancer. IFNαR1/R2 is an emerging therapeutic target for various types of diseases involving modulation of Type I interferon signaling.

Alternate Names: IFNA-R2, IFNAR, IFNaR, IFNAR1/R2, interferon-α/β receptor 2