Immobilized human NK3R fragment at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human NK3R Monoclonal Antibody (Cat. No. CABh-24118) with half maximal effective concentration (EC50) range of 14.9-59.4 ng/mL (QC tested).

Anti-Human NK3R Monoclonal Antibody

Product Code: CABh-24118
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: NK3R N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # P29371
Purification: Affinity Enrichment
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as protectant
Shipping: Frozen Ice Packs
Storage: -20’C
Reconstitution Information:

For best performance, we strongly recommend you reconsitute the lyophilized product with deionized water to a stock solution of 500 µg/mL.
Solubilize for 20 minutes at room temperature with occasional gentle mixing. Avoid shaking or vortexing.

For 25µg product size:
Reconstitute with 50 µL sterile deionized water.

For 100µg product size:
Reconstitute with 200 µL sterile deionized water.

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: signaling through phosphatidylinositol hydrolysis by phospholipase C as well as activation of adenylate cyclase activity resulting in increased intracellular levels of cyclic AMP
Ligand/Receptor: neurokinin B (tachykinin neurokinin 3)
Cell Type: Podocytes, Retinal bipolar cells, Other brain neurons
Molecular Family: G protein-coupled receptor
Gene ID: P29371
Product Name: NK3R, Monoclonal Antibody
Human neurokinin-3 receptor (NK3R) is a 7-transmembrane G protein-coupled receptor (GPCR). NK3R is a Class A GPCR. Widely distributed throughout the central and peripheral nervous systems, NK3R serves as the primary receptor for the endogenous neuropeptide neurokinin B (NKB). NK3R binding to its ligand NKB, activates signaling through phosphatidylinositol hydrolysis by phospholipase C as well as activation of adenylate cyclase activity resulting in increased intracellular levels of cyclic AMP. Signaling through NK3R acts as a master rheostat for the hypothalamic-pituitary-gonadal (HPG) axis, controlling reproductive development, pubertal onset, and core thermoregulation. NK3R is an emerging therapeutic target for several disorders such as schizophrenia, drug addiction, and pre-eclampsia during pregnancy. Human NK3R protein has >80% sequence homology with mouse NK3R.

Alternate Names: TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL, Tachykinin receptor 3, TAC3R, NK3