Immobilized human IFNαR1/R2 heterodimer (Cat. No. CSP-24025-A1B1) at 2 μg/mL (100 μL/well) can bind mouse Anti-Human IFNαR1/R2 Monoclonal Antibody (Cat. No. CABh-24025) with half maximal effective concentration (EC50) range of 5.8-23.2 ng/mL (QC tested).
Anti-Human IFNαR1/R2 Monoclonal Antibody (Cat. No. CABh-24025) binds specifically to immobilized human IFNαR1/R2 heterodimer (Cat. No. CSP-24025-A1B1) at 2 μg/mL (100 μL/well) with half maximal effective concentration (EC50) range of 5.8-23.2 ng/mL (QC tested) compared to binding to either IFNαR1 or IFNαR2 monomer.

Anti-Human IFN alpha-R1/R2 Monoclonal Antibody

Product Category: All Products

Product Code: CABh-24025
Isotype: IgG1
Specificity: Human
Host Species: Mouse
Immunogen: IFNαR1 and IFNαR2 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # P17181 for IFNαR1; P48551 for IFNαR2
Purification: Affinity Enrichment
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as a protectant
Shipping: Frozen Ice Packs
Storage: On receipt, store at -20 C or lower for long term storage. This product is stable at: -20 to -70 C for 12 months from date of receipt in lyophilized state. -70 C for 3 months after reconstitution under sterile conditions. Avoid repeated freeze-thaw cycles
Reconstitution Information:

For best performance, we strongly recommend you reconstitute the lyophilized product with deionized water to a stock solution of 500 µg/mL.
Solubilize for 20 minutes at room temperature with occasional gentle mixing. Avoid shaking or vortexing.

For 25µg product size:
Reconstitute with 50 µL sterile deionized water.

For 100µg product size:
Reconstitute with 200 µL sterile deionized water.

Datasheet

MSDS

Structure: Each subunit contains an N-terminal ligand binding domain containing two (IFNαR2) or four (IFNαR1) fibronectin type II-like subdomains, a transmembrane domain, and a cytoplasmic domain.
Function: Activates the JAK-STAT, MAPK, PI3K, and Akt signaling pathways
Ligand/Receptor: Type I IFNs
Cell Type: Nearly ubiquitous expression on all cell types but enhanced expression on peripheral blood B cells and monocytes
Molecular Family: Cytokine receptor
Gene ID: P17181; P48551
Product Name: IFNαR1/R2, Monoclonal Antibody
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human interferon-alpha/beta receptor (IFNaR, IFNαR1/R2) is a Type 1 Interferon Receptor, primarily located on the cell plasma membrane. IFNαR1/R2 is a heterodimeric cell surface receptor complex composed of two subunits IFNαR1 and IFNαR2. IFNαR1/R2 recognizes type I interferon (IFN) cytokines such as IFN-α, IFN-β and others. Upon binding to type I IFNs, IFNαR1/R2 activates the JAK-STAT, MAPK, PI3K, and Akt signaling pathways. As Type 1 interferon signaling plays important roles in immune responses, dysregulation of IFNαR1/R2 activated pathways has been associated with various diseases, such as neurodegenerative diseases, autoimmune disorders and cancer. IFNαR1/R2 is an emerging therapeutic target for various types of diseases involving modulation of Type I interferon signaling.

Alternate Names: IFNAR1, IFNAR2, IFNAR, IFNaR, IFNA-R1/R2, interferon-Alpha/Beta Receptor, interferon-α/β receptor