Immobilized human Claudin 4 VLP (Cat. No. CMP-24006) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 4 antibody with half maximal effective concentration (EC50) range of 48.6-194.4 ng/mL (QC tested).
The mean peak diameter (nm) of the CMP is 199.2 with a range of 189.2-209.2 with more than 95% intensity as determined by dynamic light scattering (DLS).

Human Claudin 4 Full Length Protein, Displayed on Virus-Like Particles (VLPs)

Product Category: Claudin

Product Code: CMP-24006
Expression Host: HEK293T
Verified Applications: ELISA and Western blot for Claudin 4-specific antibody binding assays.
Suggested Applications: ELISA for Claudin 4-specific antibody binding assays; animal immunization, RUO.
Amino Acid Range: Met1 – Val209

For Research Use Only (RUO)

Add to Quote

Ready to buy now?
Email us at [email protected] and we’ll help you place your order directly.

Formulation: 0.45μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Claudin 4 (CLDN4) is an integral membrane protein with 4 transmembrane domains. The full length human protein contains 209 amino acids (Met1 – Val209; UniProt# NP_001296.1) is displayed on Virus-Like Particles (VLPs), (CMP-24006) and mimics the native protein conformation on the cell surface. Claudin 4 Virus-Like Particle (VLP), (Claudin 4 CMP) are expressed in HEK293T cells. The Claudin 4 CMP has potent binding to specific antibodies.
Product Name: Claudin 4
Predicted Molecular Weight: N/A
Protein Construct: Claudin 4 protein contains 209 amino acids (Met1 – Val209; UniProt# NP_001296.1), and is displayed on Virus-Like Particles (VLPs), that mimics the native protein conformation on the cell surface.

Background and Alternate Names

Claudin 4, also known as CLDN4, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, two intracellular loops, both N-terminus and C-terminus ends towards the cytosol. Human Claudin 4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma. As a pancreatic cancer marker in cell-blocks of effusion specimens, it has also been found to have a superior performance to BerEp4 staining.

Alternate Names: Claudin-4, CLDN4