MW: Molecular Weight marker reduced condition
NR: soluble GLP1R under non-reduced condition
Immobilized human soluble GLP1R (Cat. No. sCMP-25034) can bind anti-human soluble GLP1R polyclonal antibody with half maximal effective concentration (EC50) range of 52.2-208.8 ng/mL (QC tested).

Human GLP1R Protein, His Tag

Product Category: GPCR

Product Code: sCMP-25034
Expression Host: HEK293T
Verified Applications: ELISA for GLP1R-specific antibody binding assays.
Suggested Applications: SPR & BLI for GLP1R-specific antibody binding assays. Animal immunization, RUO.
Amino Acid Range: R24-E138

For Research Use Only (RUO)

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Shipping: Frozen Dry Ice
Storage: On receipt, store at -70 C or lower for long term storage. This product is stable at: -70 C for 6 months from date of receipt. Avoid repeated freeze-thaw cycles

Datasheet

MSDS

Human glucagon-like peptide-1 receptor (GLP1R) is a member of the class B family of G protein-coupled receptor (GPCR). The recombinant GLP1R protein (sCMP-25034) contains the GLP1R extracellular N-terminus (UniProt# P43220, amino acids Arg24-Glu138) with a His tag at the C-terminus. This protein is expressed in HEK293T cells. The recombinant human GLP1R protein can bind GLP1R-specific antibodies. This recombinant GLP1R protein can be used as an antigen for in vitro assays and antibody screening, and as an immunogen for immunization to generate antibodies targeting more conformational epitopes.
Product Name: GLP1R, soluble protein
UniProt #: P43220
Predicted Molecular Weight: 13.5 kDa
SDS PAGE Molecular Weight: The migration range of the protein with glycosylation under non-reducing conditions is between 20 and 40 kDa on SDS PAGE.
Protein Construct: The recombinant GLP1R protein contains the GLP1R extracellular N-terminuswith a His tag at the C-terminus.

Background and Alternate Names

Human glucagon-like peptide-1 receptor (GLP1R) is a member of the class B family of G protein-coupled receptor (GPCR) and found on beta cells of the pancreas as well as on neurons of the brain. GLP1R is the receptor of glucagon-like peptide 1 (GLP-1). GLP1R contains an extracellular N-terminus that binds GLP-1 resulting in enhanced insulin secretion and production. Due to its involvement in intracellular signaling pathways that regulate insulin secretion, glucose metabolism, and satiety, GLP1R and GLP-1 are important targets for therapeutics for the treatment of type 2 diabetes and weight loss.

Alternate Names: GLP-1-R, GLP-1R, glucagon like peptide 1 receptor