Bioactive, Human CD2 Protein Dimer, His-Avi Tag

Human cluster of differentiation 2 (CD2), is a Type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD2 is also known as T-cell surface antigen T11/Leu-5, lymphocyte function-associated antigen-2 (LFA-2), lymphocyte function-associated antigen-3 receptor (LFA-3 receptor), sheep red blood cell receptor (SRBC), CD2 molecule, erythrocyte receptor, and rosette receptor. CD2 contains an extracellular domain with two immunoglobulin-like domains (Ig-like), a transmembrane domain, and a cytoplasmic domain. CD2 is expressed on human T cells and natural killer (NK) cells. CD2 interacts with itself or other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58), to play an important role in mediating cell adhesion and signal transduction. CD2 is expressed in a variety of cancer cells, including T-cell lymphomas and leukemias and is also found in B-cell neoplasms. CD2 expression can serve as a prognostic biomarker for these types of cancer. CD2 is an emerging target of cancer therapeutics.