GPCR PAR1 or DRD2-Specific Monoclonal Antibodies Can Detect the Target Expressed on Live Cell Surfaces by Flow Cytometry Poster Abstract Antibody staining of G protein-coupled receptors (GPCRs) on live cells is important for studying receptor expression, localization, and dynamics in their native, functional state. This approach provides a more accurate view of receptor behavior than […]
Recombinant Bioactive CXCR4 or CXCR5 on Virus-Like Nanoparticles Can Bind to Their Chemokine Ligand CXCL12 or CXCL13 Download the Poster Poster Abstract CXCR4 and CXCR5 are G-protein coupled receptors (GPCRs). CXCR4 is a receptor for chemokine CXCL12 and a co-receptor for HIV to infect CD4 T-cells. CXCR5 is a receptor for chemokine CXCL13. The overexpression […]
Recombinant G-Protein Coupled Chemokine Receptors CXCR4 and CXCR5 on Nanoparticles are Bioactive, Binding to the Chemokine Ligands Download the Poster Poster Abstract The selective chemokine and receptor interactions are critical in inflammatory responses. CXCR4 and CXCR5 are G-protein coupled cytokine receptors (GPCRs). CXCR4 is a receptor for chemokine CXCL12 and a co-receptor for HIV to […]
Engineered Immune Checkpoint CD28 and CTLA-4 Homodimer Proteins Demonstrate Potent Binding Affinities to Their Ligand CD80 Download the Poster Poster Abstract CD28 and CTLA-4 are immune checkpoint proteins on the T cell surface as homodimers and bind to the same ligands CD80 (B7-1) and CD86 (B7-2) on antigen presenting cells. However, CD28 and CTLA-4 play […]
Engineered novel CD4 cis-dimer protein significantly enhances the binding of HIV-1 envelope glycoproteins Download the Poster Poster Abstract The CD4 molecule on the T-cell surface can present as monomer and dimer forms. Dimeric CD4 can be important for T-cell activation. As the primary receptor of HIV, the interaction between CD4 and HIV envelope glycoprotein (Env) […]
Engineered novel cytokine receptors IFNγR1, IL10Rα and IFNαR1/2 cis-dimers significantly enhance the binding of the relevant cytokines IFNγ, IL-10 and IFNα Download the Poster Poster Abstract Cytokines initiate signaling on target cells by engaging the ectodomains (ECDs) of cell surface receptors. Cytokine receptor dimeric forms are critical for cytokine ligand binding. To mimic the dimeric […]
Engineered Novel CD155 and Nectin-4 Homodimer Proteins Dramatically Enhance Binding Affinities to Their Receptor TIGIT Compared to Respective Monomers Download the Poster Poster Abstract Understanding immune checkpoint receptor and ligand interactions is crucial for immuno-oncology. Nectin-4 and CD155 are part of the Nectin/Nectin-like family ligands of TIGIT (an inhibitory receptor on lymphocytes), can form homodimers […]
