Dimeric Cytokine Receptors

Native-like Structure. Bioactive Performance. Reliable Results.

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Conigen’s recombinant cytokine receptors, including IFNγR1, IL10Rα, and IFNαR1/R2 mimic native quaternary structures essential for signal transduction and immune regulation. These proteins enable accurate modeling of ligand-induced dimerization and receptor activation.

Cytokine receptors translate extracellular cytokine signals into intracellular responses. Lacking intrinsic kinase activity, they rely on dimerization to activate JAK-STAT and other signaling pathways. Preformed or ligand-induced dimerization drives immune activation, proliferation, and differentiation. Structural fidelity is key to preserving binding specificity and downstream signaling efficiency.

Conigen’s dimeric cytokine receptors support high-sensitivity assays, mechanistic studies, and therapeutic development across autoimmunity, cancer, and inflammation.

Available Cytokine Receptors

ProductTagSpeciesProduct CodeDetailshf:tax:product_taghf:tax:pa_species
IFNγ R1/CD119All Tags, HisAll Species, HumanCSP-24015Show detailsall-tags hisall-species human
IL-10RαAll Tags, HisAll Species, HumanCSP-24018Show detailsall-tags hisall-species human
IFNα-R1/R2All Tags, HisAll Species, HumanCSP-24025-A1B1Show detailsall-tags hisall-species human
IL-2Rβ/γAll Tags, Avi, HisAll Species, HumanCSP-24045-A1B5Show detailsall-tags avi hisall-species human
IL-15RαAll Tags, His-AviAll Species, HumanCSP-24064Show detailsall-tags his-aviall-species human
gp130All Tags, His-AviAll Species, HumanCSP-24081-03Show detailsall-tags his-aviall-species human
GCSFRAll Tags, His-AviAll Species, HumanCSP-24086Show detailsall-tags his-aviall-species human
EpoRAll Tags, His-AviAll Species, HumanCSP-24087Show detailsall-tags his-avicynomolgus-rhesus-macaque
PRLRAll Tags, His-AviAll Species, HumanCSP-24089Show detailsall-tags his-aviall-species human
IFNγR1All Tags, HisAll Species, MouseCSP-25156-01Show detailsall-tags hisall-species mouse
IL-15RαAll Tags, HisAll Species, MouseCSP-25158-01Show detailsall-tags hisall-species mouse
IL-6RbAll Tags, HisAll Species, MouseCSP-25159-01Show detailsall-tags hisall-species mouse
PRLRAll Tags, HisAll Species, MouseCSP-25160-01Show detailsall-tags hisall-species mouse
CD95 (Fas)All Tags, HisAll Species, HumanCSP-25163-01Show detailsall-tags hisall-species human
IL-4RαAll Tags, HisAll Species, HumanCSP-25219-01Show detailsall-tags hisall-species human
IL-4RαAll Tags, HisAll Species, MouseCSP-25220-01Show detailsall-tags hisall-species mouse
IL-6RαAll Tags, HisAll Species, HumanCSP-25223-01Show detailsall-tags hisall-species human
IL-6RαAll Tags, HisAll Species, MouseCSP-25224-01Show detailsall-tags hisall-species mouse
IL-7Rα / TSLP RAll Tags, His, StrepAll Species, MouseCSP-25242-A1B6Show detailsall-tags his strepall-species mouse
IL-6Rα/gp130All Tags, His, StrepAll Species, HumanCSP-25249-A1B6Show detailsall-tags his strepall-species human
IL-10Rα/IL-10RβAll Tags, His, StrepAll Species, HumanCSP-25251-A1B6Show detailsall-tags his strepall-species human
IL6R / gp130All Tags, His, StrepAll Species, MouseCSP-25256-ABShow detailsall-tags his strepall-species mouse
IFNγR1All Tags, HisAll Species, Rhesus MacaqueCSP-25295-01Show detailsall-tags hisall-species rhesus-macaque
IL6STAll Tags, HisAll Species, Rhesus MacaqueCSP-25296-01Show detailsall-tags hisall-species rhesus-macaque

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We offer a wide range of recombinant conformational proteins and antibodies, and our catalog is rapidly growing. If you don’t see what you need or have a custom project in mind, send us a request!
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Spotlight: IFNαR1/R2

IFNaR1 protein prediction
Bioactive Performance IFNαR1 and IFNαR2 form a heterodimeric receptor complex that mediates type I interferon signaling. Conigen’s IFNαR1/R2 protein heterodimer mimics native structural integrity, showing significantly enhanced binding to type I interferon compared to monomeric forms.
Human IFNαR1/R2 heterodimer, His-Tag (CSP-24025-A1B1), IFNαR1 or IFNαR2 monomer binding to Type I interferon (IFN) as measured by ELISA. IFNαR1/R2 heterodimer significantly enhances the binding to IFN compared to each monomer. The IFN (0.2 μg/ml) was coated on 96-well microtiter plates and detected by serial dilutions of IFNαR heterodimer or monomers.

This structurally optimized IFNαR1/R2 complex provides a superior tool for interferon biology studies, antiviral research, and immunotherapy development.