Conigen’s MAS1-specific mouse mAb targeting the 36aa N-terminal domain can potently bind the full length human MAS1 expressed on live cells by flow cytometry and the N-terminus antigen by ELISA. 

MAS1 (UniProt# P04201) plays a key role in the renin–angiotensin system (RAS), which regulates blood pressure, fluid balance, and cardiovascular function. Unlike classical angiotensin receptors such as AT1 and AT2, MAS1 is considered part of the protective arm of the RAS. Its primary endogenous ligand is angiotensin-(1–7), a peptide that counteracts many of the harmful effects of angiotensin II.

The MAS1 receptor has gained increasing attention in biomedical research due to its therapeutic potential. It is being explored as a target for treating hypertension, heart failure, and even complications related to metabolic and pulmonary diseases. Several commercial antibodies targeting MAS1 are available for research use, primarily as rabbit polyclonals with a smaller number of mouse monoclonals from other suppliers, with applications spanning Western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation at denatured and fixed cell conditions. However, antibodies for detection of MAS1 on live cells could not be found.

Conigen’s MAS1-specific live cell staining antibody provides an important tool to study MAS1 expression on live cells including primary cells and transfected cells for research and drug discovery.