Immobilized human CXCR4 VLP (Cat. No. CMP-24005) at 5 μg/mL (100 μL/well) can bind anti-human CXCR4 monoclonal antibody with half maximal effective concentration (EC50) range of 5.5-22 ng/mL (QC tested).
Immobilized human CXCL12 at 5 μg/mL (100 μL/well) can bind human CXCR4 VLP (Cat. No. CMP-24005) (QC tested).
The mean peak diameter (nm) of the CMP is 193.8 with a range of 173.8-213.8 with more than 95% intensity as determined by dynamic light scattering (DLS).

Human CXCR4 Full Length Protein, Displayed on Virus-Like Particles (VLPs)

Product Category: GPCR

Product Code: CMP-24005
Expression Host: HEK293T
Verified Applications: ELISA for CXCR4-specific antibody binding assays.
Suggested Applications: Animal immunization, RUO.

For Research Use Only (RUO)

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Formulation: 0.45μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: On receipt, store at -70 C or lower for long term storage. This product is stable at: -70 C for 6 months from date of receipt. Avoid repeated freeze-thaw cycles

Datasheet

MSDS

Human CXCR4 (C-X-C motif chemokine receptor 4) is a receptor for chemokine CXCL12 and co-receptor for HIV-1 envelope glycoprotein (Env), also known as FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, WHIMS1, and D2S201E. CXCR4 (CMP-24005) is a G protein-coupled receptor (GPCR) with seven transmembrane domains. The human CXCR4 full length protein (amino acids Met1-Ser352; UniProt# P61073), displayed on Virus-Like Particles (VLPs), (CMP-24005) mimics the native protein conformation on the cell surface. The CXCR4 Virus-Like Particle (VLP), (CXCR4 CMP) is expressed in HEK293 cells. The CXCR4 CMP has potent binding to its ligands CXCL12 and HIV-1 Env, and the CXCR4-specific antibodies.
Product Name: CXCR4, VLP
UniProt #: P61073
Protein Construct: The human CXCR4 full length protein, displayed on Virus-Like Particles, and mimics the native protein conformation on the cell surface.

Background and Alternate Names

C-X-C chemokine receptor type 4 (CXCR4) is also known as CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is a G protein-coupled receptor (GPCR) for the C-X-C motif chemokine 12 (CXCL12), also known as stromal cell-derived factor 1 (SDF-1). CXCR4 also acts as a co-receptor for HIV infection.

Alternate Names: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, WHIMS1, and D2S201E