Mouse IL-6Rb Protein Dimer, His Tag

Interleukin-6 receptor subunit beta (IL-6Rb) is a transmembrane protein and a member of the class of tall cytokine receptors. IL-6Rb is also known as Interleukin 6 Cytokine Family Signal Transducer (IL6ST), Cluster of Differentiation 130 (CD130), CDW130, and glycoprotein 130 (gp130). IL-6Rb serves as a shared signal transducing subunit of the receptor complexes for mouse cytokines, including interleukin-6 (IL-6), that mediate highly diverse biological processes. IL-6Rb can form homodimers and heterodimers with other cytokine receptors (i.e., IL-6 receptor alpha (IL-6Ra)) in response to cytokine binding. The homodimerization or heterodimerization of IL-6Rb is key to initiating intracellular signaling pathways. The extracellular domain of IL-6Rb includes an N-terminal immunoglobulin-like (Ig-like) domain (D1), a cytokine-binding homology region (CHR, D2D3), and three membrane-proximal fibronectin type III domains (FNIII, D4 to D6) followed by a transmembrane domain and cytoplasmic domain. It has been found that dysregulation of IL-6Rb expression and signaling mediates progression for multiple types of cancer and autoimmune diseases. Mouse IL-6Rb, the murine homolog of human IL-6Rb with conserved structural domains, is a species-specific tool essential for basic research, translational research and preclinical studies.