Anti-Human CALRL Monoclonal Antibody

Human calcitonin receptor-like receptor (CALRL), is a 7-transmembrane G protein-coupled receptor (GPCR). It is a Class B GPCR that plays a critical role in cardiovascular, lymphatic, and nervous system physiology. Unlike many GPCRs, CALRL requires association with receptor activity-modifying proteins (RAMPs) to determine its ligand specificity and functional identity. Upon ligand binding, CALRL primarily activates guanine nucleotide-binding proteins (G proteins), leading to increased intracellular cyclic AMP (cAMP) levels and downstream signaling cascades. These pathways influence processes such as vasodilation, cell proliferation, and fluid homeostasis. Clinically, CALRL is significant due to its involvement in diseases like migraine, cardiovascular disorders, and cancer. CGRP receptor antagonists targeting the CALRL-RAMP1 complex have become effective therapies for migraine treatment. Additionally, dysregulation of adrenomedullin signaling through CALRL has been linked to tumor progression and poor prognosis in certain cancers. Human CALRL protein has ~90% sequence homology with mouse CALRL.