Immobilized human CCR4 fragment at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human CCR4 Monoclonal Antibody (Cat. No. CABh-25382) with half maximal effective concentration (EC50) range of 14.6-58.4 ng/mL (QC tested).

Anti-Human CCR4 Monoclonal Antibody

Product Code: CABh-25382
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: CCR4 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # P51679
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as protectant
Shipping: Frozen Ice Packs
Storage: -20’C
Reconstitution Information:

For best performance, we strongly recommend you reconsitute the lyophilized product with deionized water to a stock solution of 500 µg/mL.
Solubilize for 20 minutes at room temperature with occasional gentle mixing. Avoid shaking or vortexing.

For 25µg product size:
Reconstitute with 50 µL sterile deionized water.

For 100µg product size:
Reconstitute with 200 µL sterile deionized water.

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Activates a phosphatidylinositol-calcium second messenger system upon ligand binding
Ligand/Receptor: CCL2, CCL4, CCL5, CCL17, and CCL22
Cell Type: CD4+ T cell subsets (Th2, Th17, Treg cells),basophil, and peripheral blood leukocytes
Molecular Family: G protein-coupled receptor
Gene ID: P51679
Product Name: CCR4, Monoclonal Antibody
Human C-C chemokine receptor type 4 (CCR4) is a 7-transmembrane G protein-coupled receptor (GPCR). CCR4 is a Class A GPCR. CCR4 is highly expressed in the thymus and to a lesser extent the spleen. Being expressed on the surfaces of specific white blood cell subsets – particularly T helper type 2 (Th2) cells, regulatory T (Treg) cells, and Th17 cells, CCR4 functions as a critical homing mechanism. CCR4 is heavily and uniformly overexpressed on malignant T-cells in several blood cancers, most notably Adult T-cell Leukemia/Lymphoma (ATLL) and aggressive Cutaneous T-cell Lymphomas (CTCLs). It also guides leukocyte trafficking, dictates immune response polarization, and mediates immunosuppression within the tumor microenvironment. CCR4 has become an important therapeutic target for cancer therapy. Human CCR4 protein has >85% sequence homology with mouse CCR4.

Alternate Names: CC-CKR-4, cluster of differentiation 194, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, C-C motif chemokine receptor 4