Immobilized human CFTR fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human CFTR Monoclonal Antibody (Cat. No. CABh-24042) with half maximal effective concentration (EC50) range of 7.6-30.4 ng/mL (QC tested).
Anti-Human CFTR Monoclonal Antibody
Product Category: All Products
Product Code: CABh-24042
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: CFTR extracellular loop 4, the exact sequence of the immunogen is proprietary.; UniProt # P13569
Function: Critical role in maintaining fluid balance across tissues such as the lungs, pancreas, and intestines
Ligand/Receptor: None
Cell Type: Epithelial cells of many organs
Molecular Family: ATP-binding cassette transporter-class ion channel
Gene ID: P13569
Product Name: CFTR, Monoclonal Antibody
UniProt #: P13569
Predicted Molecular Weight: N/A
Protein Construct: N/A
Background and Alternate Names
Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), is a 12-transmembrane ATP-binding cassette (ABC) transporter-class ion channel protein but uniquely acts as an ion channel regulated by ATP binding and phosphorylation. CFTR functions as a chloride and bicarbonate ion channel in epithelial cells. It plays a critical role in maintaining fluid balance across tissues such as the lungs, pancreas, and intestines. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by thick mucus buildup, chronic lung infections, and impaired digestion. Human CFTR protein has ~85% sequence homology with mouse CFTR.
Immobilized human CFTR fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human CFTR Monoclonal Antibody (Cat. No. CABh-24042) with half maximal effective concentration (EC50) range of 7.6-30.4 ng/mL (QC tested).