MW: Molecular Weight marker reduced condition
Detection of CRFR2 expressed on HEK293 cell surface transiently transfected with full-length human CRFR2 by Flow Cytometry. HEK293 cell line transfected with human CRFR2 was stained with isotype control (black curve) or mouse Anti-Human CRFR2 Monoclonal Antibody (Cat. No. CABh-25328) (green curve) by APC-conjugated Anti-Mouse IgG Secondary Antibody.

Anti-Human CRFR2 Monoclonal Antibody

Product Category: Antibody

Product Code: CABh-25328
Isotype: IgG2a
Specificity: Detects human corticotropin-releasing hormone receptor 2/CRFR2 transfectants but not irrelevant transfectants in flow cytometry.
Host Species: Mouse
Immunogen: CRFR2 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # Q13324
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA, Flow cytometry
Recommended Usage: ELISA: starting concentration 1 µg/mL Flow cytometry: 0.8 µg/1E6 cells

For Research Use Only (RUO)

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Formulation: 0.22μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: determines tissue vascularization
Ligand/Receptor: corticotropin-releasing hormone (CRH)
Cell Type: Multiple cell types including neurons, endothelial and smooth muscle cells
Molecular Family: G protein-coupled receptor
Gene ID: Q13324
Product Name: CRFR2, Monoclonal Antibody
UniProt #: Q13324

Background and Alternate Names

Human corticotropin-releasing hormone receptor 2 (CRFR2), is a 7-transmembrane G protein-coupled receptor (GPCR). CRFR2 is a Class B GPCR that binds corticotropin-releasing hormone (CRH) to promote the activation of adenylate cyclase, leading to increased intracellular cAMP levels. It has been found that CRFR2 is a critical component of a pathway necessary for tonic inhibition of adult neovascularization, making CRFR2 a potential therapeutic target for modulation of angiogenesis in cancer and ischaemic cardiovascular disease. Human CRFR2 protein has >90% sequence homology with mouse CRFR2.

Alternate Names: CRHR2, CRF-RB, CRF2, HM-CRF