Immobilized human DRD5 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human DRD5 Monoclonal Antibody (Cat. No. CABh-25365) with half maximal effective concentration (EC50) range of 61-244 ng/mL (QC tested).
Anti-Human DRD5 Monoclonal Antibody
Product Category: All Products
Product Code: CABh-25365
Isotype: IgG2b
Specificity: Human
Host Species: Mouse
Immunogen: DRD5 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # P21918
Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Ligand binding promotes synthesis of cAMP by adenylyl cyclase to stimulate biphasic accumulation of cAMP
Ligand/Receptor: D1 subtype dopamine
Cell Type: Neurons in the central nervous system and epithelial cells in the kidney
Molecular Family: G protein-coupled receptor
Gene ID: P21918
Product Name: DRD5, Monoclonal Antibody
UniProt #: P21918
Predicted Molecular Weight: N/A
Protein Construct: N/A
Background and Alternate Names
Human Dopamine receptor D5 (DRD5) is a Class A 7-transmembrane G protein-coupled receptor (GPCR). DRD5 is highly expressed in neurons in the central nervous system and epithelial cells in the kidney. DRD5 is a therapeutic target for agonists and antagonists due to its involvement in memory, immunity, and locomotion as well as in diseases and disorders such as ADHD, Parkinson’s disease, and Schizophrenia. Human DRD5 protein has >80% sequence homology with mouse DRD5, respectively.
Immobilized human DRD5 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human DRD5 Monoclonal Antibody (Cat. No. CABh-25365) with half maximal effective concentration (EC50) range of 61-244 ng/mL (QC tested).