Immobilized human EDNRA fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human EDNRA Monoclonal Antibody (Cat. No. CABh-25397) with half maximal effective concentration (EC50) range of 1.8-7 ng/mL (QC tested).

Anti-Human EDNRA Monoclonal Antibody

Product Category: Antibody

Product Code: CABh-25397
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: EDNRA N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # P25101
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as protectant
Shipping: Frozen Ice Packs
Storage: -20’C
Reconstitution Information:

For best performance, we strongly recommend you reconsitute the lyophilized product with deionized water to a stock solution of 500 µg/mL.
Solubilize for 20 minutes at room temperature with occasional gentle mixing. Avoid shaking or vortexing.

For 25µg product size:
Reconstitute with 50 µL sterile deionized water.

For 100µg product size:
Reconstitute with 200 µL sterile deionized water.

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: vasoconstriction and cell proliferation
Ligand/Receptor: guanine nucleotides
Cell Type: mainly vascular and pulmonary smooth muscle cells
Molecular Family: G protein-coupled receptor
Gene ID: P25101
Product Name: EDNRA, Monoclonal Antibody
UniProt #: P25101
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human endothelin receptor type A (EDNRA), is a 7-transmembrane G protein-coupled receptor (GPCR). EDNRA is a Class A GPCR that binds guanine nucleotides. EDNRA modulates vasoconstriction and cell proliferation and has been associated with many diseases such as massive atherosclerotic stroke, intracranial aneurysm, migraine, and various tumors. Recently EDNRA has been the focus of possible anti-tumor therapies. Human EDNRA protein has >95% sequence homology with mouse EDNRA.

Alternate Names: ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA