Detection of GIPR in HEK293 human cell line transiently transfected with human GIPR by Flow Cytometry. HEK293 cell line transfected with human GIPR was stained with isotype control (black curve) or Mouse Anti-Human GIPR Monoclonal Antibody (Cat. No. CABh-25329) (green curve) by APC-conjugated Anti-Mouse IgG Secondary Antibody.

Anti-Human GIPR Monoclonal Antibody

Antibody

Product Code: CABh-25329
Isotype: IgG2a
Conjugate: Unconjugated
Specificity: Detects human gastric inhibitory polypeptide receptor/GIPR transfectants but not irrelevant transfectants in flow cytometry.
Host Species: Mouse
Immunogen: GIPR N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # P48546
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA, Flow cytometry
Recommended Usage: ELISA: starting concentration 1 µg/mL. Flow cytometry: 0.2-0.8 µg/1E6 cells

For Research Use Only (RUO)

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Formulation: 0.22μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: stimulates insulin release
Ligand/Receptor: gastric inhibitory polypeptide (GIP)
Cell Type: Beta-cells
Molecular Family: G protein-coupled receptor
Gene ID: P48546
Product Name: Anti-huGIPR
Human gastric inhibitory polypeptide receptor (GIPR), also called GIP-R, PGQTL2, is a 7-transmembrane G protein-coupled receptor (GPCR) belonging to the Class B GPCR family. GIPR is highly expressed in beta-cells in the pancreas. Upon gastric inhibitory polypeptide (GIP) (also known as glucose-dependent insulinotropic polypeptide) ligand binding, activates Gs–cAMP signaling, leading to glucose-dependent insulin secretion. GIPR is an important therapeutic target in metabolic diseases including Type 2 diabetes and obesity. Human GIPR protein has >95% and ~80% sequence homology with macaque and mouse GIPR, respectively.

Alternate Names: GIP-R, PGQTL2, glucose-dependent insulinotropic polypeptide receptor