Immobilized human GPR126 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human GPR126 Monoclonal Antibody (Cat. No. CABh-25392) with half maximal effective concentration (EC50) range of 6.6-26.2 ng/mL (QC tested).
Detection of GPR126 in HEK293 human cell line transiently transfected with human GPR126 by Flow Cytometry. HEK293 cell line transfected with human GPR126 was stained with isotype control (black curve) or mouse Anti-Human GPR126 Monoclonal Antibody (Cat. No. CABh-25392) (green curve) by APC-conjugated Anti-Mouse IgG Secondary Antibody.

Anti-Human GPR126 Monoclonal Antibody

Product Category: Antibody

Product Code: CABh-25392
Isotype: IgG1
Specificity: Detects human G protein-coupled receptor 126/GPR126 transfectants but not irrelevant transfectants in flow cytometry.
Host Species: Mouse
Immunogen: GPR126 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # Q86SQ4
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA, Flow cytometry
Recommended Usage: ELISA: starting concentration 1 µg/mL Flow cytometry: 0.8 µg/1E6 cells

For Research Use Only (RUO)

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Formulation: 0.22μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: mediate myelination
Ligand/Receptor: collagen IV and laminin-211 promoting cyclic adenosine monophosphate (cAMP)
Cell Type: excitatory and inhibitory neurons, and microglia
Molecular Family: G protein-coupled receptor
Gene ID: Q86SQ4
Product Name: GPR126, Monoclonal Antibody
UniProt #: Q86SQ4
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human G protein-coupled receptor 126 (GPR126), is a 7-transmembrane G protein-coupled receptor (GPCR). GPR126 is a member of the adhesion GPCR family. GPR126 is essential for Schwann cell myelination. However, it has been found that GPR126 can have a pathological role in degenerative joint disorders, scoliosis, tumorigenesis and angiogenesis making it a target for potential therapeutics. Human GPR126 protein has >90% sequence homology with mouse GPR126.

Alternate Names: ADGRG6, APG1, DREG, PS1TP2, VIGR, LCCS9, adhesion G protein-coupled receptor G6, PR126