Immobilized human GPR17 fragment at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human GPR17 Monoclonal Antibody (Cat. No. CABh-25369) with half maximal effective concentration (EC50) range of 1.2-4.8 ng/mL (QC tested).

Anti-Human GPR17 Monoclonal Antibody

Product Category: Antibody

Product Code: CABh-25369
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: GPR17 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # Q13304
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as protectant
Shipping: Frozen Ice Packs
Storage: -20’C
Reconstitution Information:

For best performance, we strongly recommend you reconsitute the lyophilized product with deionized water to a stock solution of 500 µg/mL.
Solubilize for 20 minutes at room temperature with occasional gentle mixing. Avoid shaking or vortexing.

For 25µg product size:
Reconstitute with 50 µL sterile deionized water.

For 100µg product size:
Reconstitute with 200 µL sterile deionized water.

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Nucleotide signaling and activation of microglia, regulation of many biological processes occurring in cells of the nervous system
Ligand/Receptor: Putative ligands including cysteinyl leukotrienes and uracil nucleotides
Cell Type: central nervous system tissues
Molecular Family: G protein-coupled receptor
Gene ID: Q13304
Product Name: GPR17, Monoclonal Antibody
UniProt #: Q13304
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human G protein-coupled receptor 17 (GPR17), is a 7-transmembrane G protein-coupled receptor (GPCR). GPR17 is a Class A GPCR and putative receptor for LTC4, LTD4, and uracil nucleotides. Due to its possible role as a modulator of myelination, GPR17 has recently received attention as a possible therapeutic target for demyelinating diseases such as multiple sclerosis (MS). Human GPR17 protein has >90% sequence homology with mouse GPR17.

Alternate Names: Uracil nucleotide/cysteinyl leukotriene receptor