Immobilized human GPR183 fragment at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human GPR183 Monoclonal Antibody (Cat. No. CABh-25355) with half maximal effective concentration (EC50) range of 3-12 ng/mL (QC tested).
Anti-Human GPR183 Monoclonal Antibody
Product Category: All Products
Product Code: CABh-25355
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: GPR183 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # P32249
Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: mediator of immune cell localization
Ligand/Receptor: oxysterols
Cell Type: immune cells, specifically B cells and T cells
Molecular Family: G protein-coupled receptor
Gene ID: P32249
Product Name: GPR183, Monoclonal Antibody
UniProt #: P32249
Background and Alternate Names
Human G-protein coupled receptor 183 (GPR183), is a 7-transmembrane G protein-coupled receptor (GPCR). It is a Class A GPCR. GPR183 is expressed on the surface of some immune cells, namely B cells and T cells. GPR183 is a receptor for oxysterols. GPR183 is a critical mediator of immune cell localization within lymph nodes. GPR183-expressing cells are attracted to locations of high oxysterol ligand concentration. During severe viral respiratory infections such as influenza A virus (IAV) and SARS-CoV-2, GPR183 plays a critical role in driving inflammation in the lungs. Human GPR183 protein has >90% sequence homology with mouse GPR183.
Immobilized human GPR183 fragment at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human GPR183 Monoclonal Antibody (Cat. No. CABh-25355) with half maximal effective concentration (EC50) range of 3-12 ng/mL (QC tested).