MW: Molecular Weight marker reduced condition

Anti-Human GPR183 Monoclonal Antibody

Product Category: All Products

Product Code: CABh-25355
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: GPR183 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # P32249
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: 0.22μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: mediator of immune cell localization
Ligand/Receptor: oxysterols
Cell Type: immune cells, specifically B cells and T cells
Molecular Family: G protein-coupled receptor
Gene ID: P32249
Product Name: GPR183, Monoclonal Antibody
UniProt #: P32249

Background and Alternate Names

Human G-protein coupled receptor 183 (GPR183), is a 7-transmembrane G protein-coupled receptor (GPCR). It is a Class A GPCR. GPR183 is expressed on the surface of some immune cells, namely B cells and T cells. GPR183 is a receptor for oxysterols. GPR183 is a critical mediator of immune cell localization within lymph nodes. GPR183-expressing cells are attracted to locations of high oxysterol ligand concentration. During severe viral respiratory infections such as influenza A virus (IAV) and SARS-CoV-2, GPR183 plays a critical role in driving inflammation in the lungs. Human GPR183 protein has >90% sequence homology with mouse GPR183.

Alternate Names: Epstein-Barr virus-induced G-protein coupled receptor 2, EBI2, G protein-coupled receptor 183, hEBI2