Immobilized human GPR52 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human GPR52 Monoclonal Antibody (Cat. No. CABh-25349) with half maximal effective concentration (EC50) range of 2-8.2 ng/mL (QC tested).
Detection of GPR52 in HEK293 human cell line transiently transfected with human GPR52 by Flow Cytometry. HEK293 cell line transfected with human GPR52 was stained with isotype control (black curve) or Mouse Anti-Human GPR52 Monoclonal Antibody (Cat. No. CABh-25349) (green curve) by APC-conjugated Anti-Mouse IgG Secondary Antibody.

Anti-GPR52 Monoclonal Antibody

Product Category: All Products

Product Code: CABh-25349
Isotype: IgG1
Specificity: Detects human and mouse G protein-coupled receptor 64/ GPR64 transfectants but not irrelevant transfectants in flow cytometry.
Host Species: Mouse
Immunogen: GPR52 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # Q9Y2T5
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA, Flow cytometry
Recommended Usage: ELISA: starting concentration 1 µg/mL Flow cytometry: 0.8 µg/1E6 cells

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as a protectant
Shipping: Product is shipped at ambient temperature.
Storage: On receipt, store at -20 C or lower for long term storage. This product is stable at: -20 to -70 C for 12 months from date of receipt in lyophilized state. -70 C for 3 months after reconstitution under sterile conditions. Avoid repeated freeze-thaw cycles
Reconstitution Information:

For best performance, we strongly recommend you reconsitute the lyophilized product with deionized water to a stock solution of 500 µg/mL.
Solubilize for 20 minutes at room temperature with occasional gentle mixing. Avoid shaking or vortexing.

For 25µg product size:
Reconstitute with 50 µL sterile deionized water.

For 100µg product size:
Reconstitute with 200 µL sterile deionized water.

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: controls various cyclic AMP (cAMP)-dependent physiological and pathological processes
Ligand/Receptor: Unknown
Cell Type: predominantly expressed in the brain, especially in the striatum
Molecular Family: G protein-coupled receptor
Gene ID: Q9Y2T5
Product Name: GPR52, Monoclonal Antibody
UniProt #: P0C5J4;Q9Y2T5
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human probable G-protein coupled receptor 52 (GPR52), is a 7-transmembrane G protein-coupled receptor (GPCR). GPCR52 is an orphan GPCR. Unlike many GPCRs, GPR52 exhibits constitutive activity, meaning it can signal in the absence of a known endogenous ligand. Due to its localization and signaling properties, GPR52 has attracted interest as a potential therapeutic target for neuropsychiatric disorders such as schizophrenia and Huntington’s disease.

Alternate Names: G-protein coupled receptor 52