Immobilized human GPR64 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human GPR64 Monoclonal Antibody (Cat. No. CABh-25391) with half maximal effective concentration (EC50) range of 8.9-35.6 ng/mL (QC tested).
Detection of GPR64 in HEK293 human cell line transiently transfected with human GPR64 by Flow Cytometry. HEK293 cell line transfected with human GPR64 was stained with isotype control (black curve) or mouse Anti-Human GPR64 Monoclonal Antibody (Cat. No. CABh-25391) (green curve) by APC-conjugated Anti-Mouse IgG Secondary Antibody.

Anti-Human GPR64 Monoclonal Antibody

Product Category: Antibody

Product Code: CABh-25391
Isotype: IgG2a
Specificity: Detects human G protein-coupled receptor 64/ GPR64 transfectants but not irrelevant transfectants in flow cytometry.
Host Species: Mouse
Immunogen: GPR64 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # Q8IZP9
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA, Flow cytometry
Recommended Usage: ELISA: starting concentration 1 µg/mL Flow cytometry: 0.8 µg/1E6 cells

For Research Use Only (RUO)

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Formulation: 0.22μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Regulation of spermatozoa maturation and rete testis fluid reabsorption
Ligand/Receptor: Unknown
Cell Type: male reproductive organs, parathyroid glands, and central nervous system
Molecular Family: G protein-coupled receptor
Gene ID: Q8IZP9
Product Name: GPR64, Monoclonal Antibody
UniProt #: Q8IZP9
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human G protein-coupled receptor 64 (GPR64), is a 7-transmembrane G protein-coupled receptor (GPCR). GPR64 is an orphan Class B GPCR. GPR64 has been found to be clinically significant for several cancers including overexpression in the Wnt signaling-dependent subgroup of medulloblastoma, ewing sarcomas, and carcinomas derived from endometrial tissue, prostate, kidney or lung. Human GPR64 protein has ~99% sequence homology with mouse GPR64.

Alternate Names: ADGRG2, EDDM6, HE6, TM7LN2, adhesion G protein-coupled receptor G2, CBAVDX