Immobilized human MCHR1 fragment at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human MCHR1 Monoclonal Antibody (Cat. No. CABh-25303) with half maximal effective concentration (EC50) range of 4.9-19.6 ng/mL (QC tested).
Detection of MCHR1 in HEK293 human cell line transiently transfected with human MCHR1 by Flow Cytometry. HEK293 cell line transfected with human MCHR1 was stained with isotype control (black curve) or Mouse Anti-Human MCHR1 Monoclonal Antibody (Cat. No. CABh-25303) (green curve) by APC-conjugated Anti-Mouse IgG Secondary Antibody.

Anti-Human MCHR1 Monoclonal Antibody

Product Category: All Products

Product Code: CABh-25303
Isotype: IgG2a
Specificity: Detects human melanin-concentrating hormone receptor 1/MCHR1 transfectants but not irrelevant transfectants in flow cytometry.
Host Species: Mouse
Immunogen: MCHR1 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # Q99705
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA, Flow cytometry
Recommended Usage: ELISA: starting concentration 1 µg/mL Flow cytometry: 0.8 µg/1E6 cells

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as a protectant
Shipping: Frozen Ice Packs
Storage: -20’C

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: regulation of appetite
Ligand/Receptor: melanin-concentrating hormone
Cell Type: Neuronal cells, endocrine cells, mesenchymal cells, and endothelial cells
Molecular Family: G protein-coupled receptor
Gene ID: Q99705
Product Name: MCHR1, Monoclonal Antibody
UniProt #: Q8JZL2;Q99705
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human melanin-concentrating hormone receptor 1 (MCHR1), also known as MCH1, is a 7-transmembrane G protein-coupled receptor (GPCR). MCHR1 is a class A GPCR. The binding of melanin-concentrating hormone (MCH) to MCHR1 is involved with regulation of appetite, as well as possibly stress, anxiety and depression. MCHR1 has become a possible therapeutic target for the treatment of metabolic diseases, such as diabetes and obesity, due to its involvement in regulation of appetite. Human MCHR1 protein has >95% sequence homology with mouse MCHR1.

Alternate Names: MCH1, GPR24, MCH-1R, MCH1R, SLC-1, SLC1