Immobilized human RXFP2 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human RXFP2 Monoclonal Antibody (Cat. No. CABh-25313) with half maximal effective concentration (EC50) range of 2.8-11 ng/mL (QC tested).

Anti-Human RXFP2 Monoclonal Antibody

Product Category: All Products

Product Code: CABh-25313
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: RXFP2 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # Q8WXD0
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as protectant
Shipping: Frozen Ice Packs
Storage: -20’C
Reconstitution Information:

For best performance, we strongly recommend you reconsitute the lyophilized product with deionized water to a stock solution of 500 µg/mL.
Solubilize for 20 minutes at room temperature with occasional gentle mixing. Avoid shaking or vortexing.

For 25µg product size:
Reconstitute with 50 µL sterile deionized water.

For 100µg product size:
Reconstitute with 200 µL sterile deionized water.

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: reproductive function, cardiovascular vasodilation
Ligand/Receptor: insulin-like peptide 3 (INSL3)
Cell Type: Main cell types around reproductive system including gubernacular cells, leydig cells
Molecular Family: G protein-coupled receptor
Gene ID: Q8WXD0
Product Name: RXFP2, Monoclonal Antibody
UniProt #: Q8WXD0
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human relaxin/insulin-like family peptide receptor 2 (RXFP2), is a 7-transmembrane G protein-coupled receptor (GPCR). RXFP2 is a Class A GPCR and insulin-like peptide 3 (INSL3) is its ligand. Although RXFP2 has been primarily studied for its role in reproductive development and function, it has been found that increased RXFP2 activity has been implicated in resistant hypertension, leading to RXFP2 being investigated as a potential therapeutic target. Human RXFP2 protein has ~98% sequence homology with mouse RXFP2.

Alternate Names: GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2, relaxin/insulin like family peptide receptor 2, relaxin family peptide receptor 2