Immobilized human RXFP4 fragment at 2 μg/mL (100 μL/well) can bind mouse Anti-Human RXFP4 Monoclonal Antibody (Cat. No. CABh-25341) with half maximal effective concentration (EC50) range of 18.1-72.4 ng/mL (QC tested).

Anti-Human RXFP4 Monoclonal Antibody

Product Category: All Products

Product Code: CABh-25341
Isotype: IgG2a
Specificity: Human
Host Species: Mouse
Immunogen: RXFP4 N-terminus, the exact sequence of the immunogen is proprietary.; UniProt # Q8TDU9
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA
Recommended Usage: ELISA: starting concentration 1 µg/mL

For Research Use Only (RUO)

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Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with 10% trehalose as protectant
Shipping: Frozen Ice Packs
Storage: -20’C
Reconstitution Information:

For best performance, we strongly recommend you reconsitute the lyophilized product with deionized water to a stock solution of 500 µg/mL.
Solubilize for 20 minutes at room temperature with occasional gentle mixing. Avoid shaking or vortexing.

For 25µg product size:
Reconstitute with 50 µL sterile deionized water.

For 100µg product size:
Reconstitute with 200 µL sterile deionized water.

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Regulation of food intake, gut motility, and other metabolic functions
Ligand/Receptor: insulin-like peptide 5 (INSL5)
Cell Type: epithelial cells, neuroendocrine cells
Molecular Family: G protein-coupled receptor
Gene ID: Q8TDU9
Product Name: RXFP4, Monoclonal Antibody
UniProt #: Q8TDU9
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human relaxin/insulin-like family peptide receptor 4 (RXFP4) is a 7-transmembrane G protein-coupled receptor (GPCR). RXFP4 is a class A GPCR. RXFP4 is highly expressed in the lower gut and is involved with the regulation of food intake, gut motility, and other functions relevant to metabolic health and disease. Recently, it has also been implicated to be involved in serotonin release. RXFP4 deficiency has been implicated in colon motility, colorectal cancer, and nasopharyngeal carcinoma. Human RXFP4 protein has ~99% sequence homology with mouse RXFP4.

Alternate Names: GPCR142, GPR100, RLN3R2, RXFPR4, relaxin family peptide/INSL5 receptor 4