Human IFNγR1 (interferon gamma receptor 1) is also known as CD119, IFNγR, IMD27A, and IMD27B. IFNγR1 protein dimer (CSP-24015) contains IFNγR1 2 extracellular domains (amino acids Glu18-Gly245, UniProt# P15260) with a homodimer motif and a His tag at the C-terminus. This protein is expressed in HEK293 cells. The IFNγR1 dimer protein is bioactive and can bind to IFNγ cytokine with dramatically increased binding potency compared to the IFNγR1 monomer. It also binds to IFNγR1-specific antibodies. This IFNγR1 dimer can be used as an immunogen for animal immunization (RUO) and as an antigen for in vitro assays and antibody screening targeting more conformational epitopes.
Protein Name: IFNγ R1/CD119
UniProt #: P15260
Predicted Molecular Weight: 98 kDa
SDS PAGE Molecular Weight: The migration range of the dimer under non-reducing condition is 90-120 kDa on SDS PAGE.
Protein Construct: IFNγR1 protein dimer contains IFNγR1 2 extracellular domainswith a homodimer motif and a His tag at the C-terminus.
Background
Interferon gamma receptor 1 (IFNγR1), also known as CD119, IMD27A and IMD27B, is a subunit of interferon gamma receptor (IFNγR). IFNγR belongs to the type II cytokine receptor family. IFNγR1 is a type I integral membrane glycoprotein containing extracellular, transmembrane and intracellular domains. The extracellular domain has two immunoglobulin-like (Ig-like) C2-type domains. The interferon gamma (IFNγ) dimer interacts with two IFNγR1 molecules to activate the cascade signaling pathway.
MW: Molecular Weight marker reduced condition
NR:
