Bioactive, Rhesus macaque PVR Protein Dimer, His Tag

Poliovirus Receptor (PVR) is a Type I transmembrane glycoprotein that belongs to the Nectin/Nectin-like family. PVR is also known as cluster of differentiation 155 (CD155), HVED, NECL5, Necl-5, PVS, TAGE4, and FLJ25946. PVR protein consists of 3 extracellular immunoglobulin-like (Ig-like) domains (D1-D3), one transmembrane region, and a C-terminal cytoplasmic domain. PVR is widely expressed on various cell types and often overexpressed on cancer cells. Upregulation of PVR in several types of human cancers is associated with a poor prognosis. Although PVR itself is not an immune checkpoint, it’s a ligand for checkpoint receptors like TIGIT (T-cell immunoreceptor with Ig and ITIM domains), CD226 (DNAM-1), and CD96. The interactions between PVR and its receptors on immune cells modulate immune responses, such as T cells and natural killer (NK) cells. This makes PVR a critical player in immune regulation and a promising target in checkpoint cancer therapies. While structurally and functionally similar to human PVR homodimer, Rhesus macaque PVR homodimer is a species-specific tool essential for preclinical studies, basic research, and translational research.