Human CXCR5 (C-X-C motif chemokine receptor 5) is a receptor for chemokine CXCL13, also known as BLR1, CD185, and MDR15. CXCR5 (BCMP-24014) is a G protein-coupled receptor (GPCR) with seven transmembrane domains. The human CXCR5 full length protein (amino acids Met1-Phe372; UniProt# P32302), displayed on Virus-Like Particles (VLPs), mimics the native protein conformation on the cell surface. The CXCR5 VLP is expressed in HEK293 cells. The CXCR5 VLP has potent binding to CXCR5-specific antibodies. Biotinylation of this product is performed by labeling surface exposed primary amino groups with biotin on a 22.4 Å spacer arm.
Product Name: Biotinylated CXCR5
UniProt #: P32302
Predicted Molecular Weight: N/A
Protein Construct: The human CXCR5 full length protein, mimics the native protein conformation on the cell surface displayed on Virus-Like Particlesbiotinylated with biotin on a 22.4 Å spacer arm.
Background and Alternate Names
C-X-C chemokine receptor type 5 (CXCR5) is also known as CD185, Burkitt lymphoma receptor 1 (BLR1) and monocyte-derived receptor 15 (MDR15). CXCR-5 is a G protein-coupled receptor (GPCR) for the C-X-C motif chemokine 13 (CXCL13). It enables T cells to migrate to lymph node and the B cell zones.
Immobilized human CXCR5 biotinylated VLP (Cat. No. BCMP-24014) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human CXCR5 antibody with half maximal effective concentration (EC50) range of 12.2-48.6 ng/mL (QC tested).