Claudin 4 (CLDN4) is an integral membrane protein with 4 transmembrane domains. The full length human protein contains 209 amino acids (Met1 – Val209; UniProt# NP_001296.1) is displayed on nanoparticles (CMP-24006) and mimics the native protein conformation on the cell surface. Claudin 4 nanoparticles (Claudin 4 CMP) are expressed in HEK293T cells. The Claudin 4 CMP has potent binding to specific antibodies.
Protein Name: Claudin 4
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Protein Construct: Claudin 4 protein contains 209 amino acids, and is displayed on nanoparticles that mimics the native protein conformation on the cell surface.
Background
Claudin 4, also known as CLDN4, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, two intracellular loops, both N-terminus and C-terminus ends towards the cytosol. Human Claudin 4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma. As a pancreatic cancer marker in cell-blocks of effusion specimens, it has also been found to have a superior performance to BerEp4 staining.
Immobilized human Claudin 4 VLP (Cat. No. CMP-24006) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 4 antibody with half maximal effective concentration (EC50) range of 48.6-194.4 ng/mL (QC tested).