Immobilized human CXCR5 VLP (Cat. No. CMP-24014) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human CXCR5 antibody with half maximal effective concentration (EC50) range of 6.4-25.7 ng/mL (QC tested).

The mean peak diameter (nm) of the CMP is 187.6 with a range of 170.9-207.8 with more than 95% intensity as determined by dynamic light scattering (DLS).

Human CXCR5 Full Length Protein, Displayed on Nanoparticles

Product Code: CMP-24014

Expression Host: HEK293T

Verified Applications: ELISA for CXCR5-specific antibody binding assays.

Suggested Applications: Animal immunization, RUO.

Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition

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Formulation: 0.45μm filtered PBS, pH 7.4

Shipping: Frozen Dry Ice

Storage: -80’C

Datasheet

MSDS

Human CXCR5 (C-X-C motif chemokine receptor 5) is a receptor for chemokine CXCL13, also known as BLR1, CD185, and MDR15. CXCR5 (CMP-24014) is a G protein-coupled receptor (GPCR) with seven transmembrane domains. The human CXCR5 full length protein (amino acids Met1-Phe372; UniProt# P32302), displayed on nanoparticles (CMP-24001) mimics the native protein conformation on the cell surface. The CXCR5 nanoparticle (CXCR5 CMP) is expressed in HEK293 cells. The CXCR5 CMP has potent binding to its ligand CXCL13 and the CXCR5-specific antibodies.

Protein Name: CXCR5

Protein Construct: The human CXCR5 full length protein, displayed on nanoparticles and mimics the native protein conformation on the cell surface.

Background

C-X-C chemokine receptor type 5 (CXCR5) is also known as CD185, Burkitt lymphoma receptor 1 (BLR1) and monocyte-derived receptor 15 (MDR15). CXCR-5 is a G protein-coupled receptor (GPCR) for the C-X-C motif chemokine 13 (CXCL13). It enables T cells to migrate to lymph node and the B cell zones.

Human CXCR5 Full Length Protein, Displayed on Nanoparticles

Datasheet

MSDS

Background

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