Immobilized human CXCR5 VLP (Cat. No. CMP-24014) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human CXCR5 antibody with half maximal effective concentration (EC50) range of 7.5-30 ng/mL (QC tested).
Immobilized human CXCL13 at 5 μg/mL (100 μL/well) can bind human CXCR5 VLP (Cat. No. CMP-24014) with half maximal effective concentration (EC50) range of 2.6-10.6 μg/mL (QC tested).
The mean peak diameter (nm) of the CMP is 187.6 with a range of 170.9-207.8 with more than 95% intensity as determined by dynamic light scattering (DLS).

Human CXCR5 Full Length Protein, Displayed on Virus-Like Particles (VLPs)

Product Category: GPCR

Product Code: CMP-24014
Expression Host: HEK293T
Verified Applications: ELISA for CXCR5-specific antibody binding assays.
Suggested Applications: Animal immunization, RUO.
Amino Acid Range: Met1-Phe372

For Research Use Only (RUO)

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Formulation: 0.45μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Human CXCR5 (C-X-C motif chemokine receptor 5) is a receptor for chemokine CXCL13, also known as BLR1, CD185, and MDR15. CXCR5 (CMP-24014) is a G protein-coupled receptor (GPCR) with seven transmembrane domains. The human CXCR5 full length protein (amino acids Met1-Phe372; UniProt# P32302), displayed on Virus-Like Particles (VLPs), (CMP-24001) mimics the native protein conformation on the cell surface. The CXCR5 Virus-Like Particle (VLP), (CXCR5 CMP) is expressed in HEK293 cells. The CXCR5 CMP has potent binding to its ligand CXCL13 and the CXCR5-specific antibodies.
Product Name: CXCR5, VLP
UniProt #: P32302
Predicted Molecular Weight: N/A
Protein Construct: The human CXCR5 full length protein, displayed on Virus-Like Particles, and mimics the native protein conformation on the cell surface.

Background and Alternate Names

C-X-C chemokine receptor type 5 (CXCR5) is also known as CD185, Burkitt lymphoma receptor 1 (BLR1) and monocyte-derived receptor 15 (MDR15). CXCR-5 is a G protein-coupled receptor (GPCR) for the C-X-C motif chemokine 13 (CXCL13). It enables T cells to migrate to lymph node and the B cell zones.

Alternate Names: BLR1, CD185, and MDR15