Protein Name: soluble GLP1R
Predicted Molecular Weight: 13.5 kDa
SDS PAGE Molecular Weight: The migration range of the protein with glycosylation under non-reducing conditions is between 20 and 40 kDa on SDS PAGE.
Protein Construct: The recombinant GLP1R protein contains the GLP1R extracellular N-terminuswith a His tag at the C-terminus.
Human glucagon-like peptide-1 receptor (GLP1R) is a member of the class B family of G protein-coupled receptor (GPCR) and found on beta cells of the pancreas as well as on neurons of the brain. GLP1R is the receptor of glucagon-like peptide 1 (GLP-1). GLP1R contains an extracellular N-terminus that binds GLP-1 resulting in enhanced insulin secretion and production. Due to its involvement in intracellular signaling pathways that regulate insulin secretion, glucose metabolism, and satiety, GLP1R and GLP-1 are important targets for therapeutics for the treatment of type 2 diabetes and weight loss.
MW: Molecular Weight marker reduced condition
NR: soluble GLP1R under non-reduced condition
Immobilized human soluble GLP1R (Cat. No. sCMP-25034) can bind anti-human soluble GLP1R polyclonal antibody with half maximal effective concentration (EC50) range of 52.2-208.8 ng/mL (QC tested).