Mouse Anti-Human DRD2 Monoclonal Antibody

Other

Product Code: CABh-24075
Isotype: IgG2a
Conjugate: Unconjugated
Specificity: Human Dopamine Receptor D2 / DRD2
Host_Species: Mouse
Immunogen: DRD2, Asp2-Tyr37; UniProt # P14416
Purification: Affinity Enrichment
Verified Applications: ELISA, Flow cytometry, LSPR
Purity: >99% purity determined by SDS-PAGE under non-reducing condition
Recommended Usage: ELISA: starting concentration 1 µg/mL. Flow cytometry: 0.5 µg/1E6 cells LSPR: Recommended maximum concentration, 100 nM

For Research Use Only (RUO)

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Formulation: 0.22μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C
Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Inhibit adenylyl cyclase activity
Ligand/Receptor: EPB41L1, PPP1R9B, NCS-1
Cell Type: Anterior pituitary gland
Molecular Family: G protein-coupled receptor
Gene ID: P14416
Product Name: Anti-huDRD2

Background

Human dopamine receptor D2 (DRD2) is a G protein-coupled receptor (GPCR) on cell surface that inhibits adenylyl cyclase activity. DRD2 contains seven transmembrane domains and is highly expressed in the anterior pituitary gland of the brain. DRD2 is the main receptor for most antipsychotic drugs and mutations in the gene encoding DRD2 have been associated with myoclonus dystonia and schizophrenia.

Alternate Names: D2DR, D2R