Bioactive Recombinant Tumor-Associated Antigen Proteins

Native-like Structure. Bioactive Performance. Reliable Results.

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Conigen’s recombinant tumor-associated antigens (TAAs), including HER2, TROP-2, and Nectin-4 mimic native quaternary conformations that are essential for understanding cancer progression and advancing targeted therapies. Many TAAs dimerize to drive oncogenic signaling or modulate immune recognition.

TAAs are aberrantly expressed proteins that serve as biomarkers and therapeutic targets in cancer. Dimerization stabilizes receptor-ligand interactions and enhances signaling, shaping the development of monoclonal antibodies, CAR-T therapies, and bispecifics. Conigen’s recombinant protein dimers mimic these native conformations, enabling high-sensitivity screening and epitope-specific discovery.

Available Tumor-Associated Antigens

ProductTagSpeciesProduct CodeDetailshf:tax:product_taghf:tax:pa_species
CD117, Protein DimerhFcAll Species, HumanCSP-25123-04Show detailshfc
Nectin-4, Protein DimerHisAll Species, HumanCSP-24016Show detailshis
TROP-2, Protein DimerFlag-HisAll Species, HumanCSP-24041-02Show detailsflag-his
CD2, Protein DimerHis-AviAll Species, HumanCSP-24095-03Show detailshis-avi
CD38, Protein DimerHis-AviAll Species, HumanCSP-24096-03Show detailshis-avi
B7H3 isoform 2lg, Protein DimerHis-AviAll Species, HumanCSP-240982lgShow detailshis-avi
B7H3 isoform 4lg, Protein DimerHis-AviAll Species, HumanCSP-240984lgShow detailshis-avi
CD117, Protein DimerHis-AviAll Species, HumanCSP-24123-03Show detailshis-avi
TROP-2, Protein DimerFlag-HisAll Species, MouseCSP-25191-02Show detailsflag-his
CD117, Protein DimerHis-AviAll Species, MouseCSP-25193-03Show detailshis-avi
CD117, Protein DimerHis-AviAll Species, Rhesus MacaqueCSP-25194-03Show detailshis-avi
Nectin-1, Protein DimerHis-AviAll Species, HumanCSP-25195-03Show detailshis-avi
Nectin-3, Protein DimerHis-AviAll Species, HumanCSP-25196-03Show detailshis-avi
PVR, Protein DimerHisAll Species, Rhesus MacaqueCSP-25297-01Show detailshis

Can’t Find the Product You Need?

We offer a wide range of recombinant conformational proteins and antibodies, and our catalog is rapidly growing. If you don’t see what you need or have a custom project in mind, send us a request!
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Spotlight: Nectin-4

Nectin-4 model prediction
Bioactive Performance Nectin-4 is a tumor-associated antigen involved in cell adhesion and immune modulation. Conigen’s Nectin-4 protein dimer mimics its native dimer configuration and shows enhanced binding to the TIGIT protein dimer compared to monomeric forms.

Human Nectin-4 protein dimer, His-Tag (CSP-24016) or Nectin-4 protein monomer binding to TIGIT protein dimer, Fc-Tag (TIGIT-Fc, CSP-24028) as measured by ELISA. Nectin-4 protein dimer significantly enhances the binding to TIGIT compared to Nectin-4 monomer. The Nectin-4 protein dimer or monomer (0.2 μg/ml) was coated on 96-well microtiter plates and detected by serial dilutions of TIGIT-Fc.

These recombinant proteins are ideal for studying receptor-ligand dynamics, therapeutic antibody development, and cancer biology research.