Recombinant Bioactive CXCR4 or CXCR5 on Virus-Like Nanoparticles Can Bind to Their Chemokine Ligand CXCL12 or CXCL13

Poster Abstract CXCR4 and CXCR5 are G-protein coupled receptors (GPCRs). CXCR4 is a receptor for chemokine CXCL12 and a co-receptor for HIV to infect CD4 T-cells. CXCR5 is a receptor for chemokine CXCL13. The overexpression of CXCR4 and CXCR5 on cancer cells makes them attractive targets for therapeutics. As seven transmembrane GPCRs, it is very […]

Recombinant G-Protein Coupled Chemokine Receptors CXCR4 and CXCR5 on Nanoparticles are Bioactive

Poster Abstract The selective chemokine and receptor interactions are critical in inflammatory responses. CXCR4 and CXCR5 are G-protein coupled cytokine receptors (GPCRs). CXCR4 is a receptor for chemokine CXCL12 and a co-receptor for HIV to infect CD4 T-cells. CXCR5 is a receptor for chemokine CXCL13. The overexpression of CXCR4 and CXCR5 on cancer cells make […]