Poster Abstract Antibody staining of G protein-coupled receptors (GPCRs) on live cells is important for studying receptor expression, localization, and dynamics in their native, functional state. This approach provides a more accurate view of receptor behavior than methods that use fixed cells, which can cause artifacts and alter the receptor’s conformation. Due to their complex […]
Poster Abstract CXCR4 and CXCR5 are G-protein coupled receptors (GPCRs). CXCR4 is a receptor for chemokine CXCL12 and a co-receptor for HIV to infect CD4 T-cells. CXCR5 is a receptor for chemokine CXCL13. The overexpression of CXCR4 and CXCR5 on cancer cells makes them attractive targets for therapeutics. As seven transmembrane GPCRs, it is very […]
Poster Abstract The selective chemokine and receptor interactions are critical in inflammatory responses. CXCR4 and CXCR5 are G-protein coupled cytokine receptors (GPCRs). CXCR4 is a receptor for chemokine CXCL12 and a co-receptor for HIV to infect CD4 T-cells. CXCR5 is a receptor for chemokine CXCL13. The overexpression of CXCR4 and CXCR5 on cancer cells make […]
