CXCR5 Proteins CXCR5 is a GPCR chemokine receptor that binds CXCL13 chemokine and supports immune cell migration and follicular immune responses. Conigen provides full-length, multi-pass recombinant CXCR5 embedded in a native-like lipid bilayer on virus-like particles (VLPs) to support receptor/ligand and antibody binding studies, assay development, and antibody discovery for difficult membrane targets. Example QC […]
GHR (Growth Hormone Receptor) Proteins Growth hormone receptor (GHR) is a type I cytokine receptor family member and the transmembrane receptor for growth hormone. GHR contains an extracellular domain with two fibronectin type III β domains, a single-pass transmembrane region, and an intracellular cytoplasmic domain that mediates downstream signaling. GHR can form preformed and growth […]
PD-1 Proteins Programmed cell death protein 1 (PD-1, CD279) is a type I transmembrane receptor expressed on T cells and B cells and a key immune checkpoint in the immunoglobulin superfamily. PD-1 binds the B7 family ligands PD-L1 and PD-L2, and PD-L1 overexpression on tumor cells can suppress immune responses by inhibiting T cell activity. […]
CD19 Proteins CD19 is a type I transmembrane glycoprotein in the immunoglobulin superfamily expressed on B cells throughout development and widely used as a marker of B cell lineage. CD19 functions as a key signaling component of the B cell receptor complex and helps regulate B cell activation and differentiation. CD19 is highly expressed in […]
CD4 Proteins CD4 is a type I transmembrane glycoprotein expressed on the surface of T cells (also known as T-cell surface antigen T4/Leu-3). The extracellular domain contains four Ig-like domains and plays a central role in MHC class II–mediated antigen recognition and T cell activation. CD4 also functions as the receptor for interleukin-16 (IL-16) and […]
B Cell Receptors and Surface Markers Native-like Structure. Bioactive Performance. Reliable Results. View All Products Conigen’s recombinant B cell receptors (BCRs), including CD19 mimic native conformations and antigen responsiveness, supporting discovery in immunology, oncology, and antibody engineering. The BCR complex enables antigen recognition and signaling in B cells, facilitating activation, differentiation, and memory formation. CD19 […]
Dimeric Siglecs Native-like Structure. Bioactive Performance. Reliable Results. View All Products Conigen’s recombinant Siglecs, including Siglec-6 mimic native structures essential for studying sialic acid recognition, immune modulation, and therapeutic intervention in inflammatory diseases and cancer. Siglecs (Sialic acid-binding immunoglobulin-like lectins) are a family of immunoregulatory receptors expressed on immune cells. They modulate responses by binding glycosylated ligands […]
Dimeric Cytokine Receptors Native-like Structure. Bioactive Performance. Reliable Results. View All Products Conigen’s recombinant cytokine receptors, including IFNγR1, IL10Rα, and IFNαR1/R2 mimic native quaternary structures essential for signal transduction and immune regulation. These proteins enable accurate modeling of ligand-induced dimerization and receptor activation. Cytokine receptors translate extracellular cytokine signals into intracellular responses. Lacking intrinsic kinase activity, […]
Bioactive Recombinant Immune Checkpoint Protein Dimers Native-like Structure. Bioactive Performance. Reliable Results. View All Products Conigen’s recombinant immune checkpoint proteins, including CD28, CD80, CTLA-4, PD-1, and TIGIT mimic native dimerization to support accurate receptor-ligand interactions and immune signaling studies. These immune checkpoint receptors are transmembrane proteins that maintain immune homeostasis by balancing activation and inhibition. […]
