Bioactive Recombinant Tumor-Associated Antigen Proteins

Native-like Structure. Bioactive Performance. Reliable Results.

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Conigen’s recombinant tumor-associated antigens (TAAs), including HER2, TROP-2, and Nectin-4 mimic native quaternary conformations that are essential for understanding cancer progression and advancing targeted therapies. Many TAAs dimerize to drive oncogenic signaling or modulate immune recognition.

TAAs are aberrantly expressed proteins that serve as biomarkers and therapeutic targets in cancer. Dimerization stabilizes receptor-ligand interactions and enhances signaling, shaping the development of monoclonal antibodies, CAR-T therapies, and bispecifics. Conigen’s recombinant protein dimers mimic these native conformations, enabling high-sensitivity screening and epitope-specific discovery.

Available Tumor-Associated Antigens

ProductTagSpeciesProduct CodeDetailshf:tax:product_taghf:tax:pa_species
CD117All Tags, hFcAll Species, HumanCSP-25123-04Show detailsall-tags hfcall-species human
Nectin-4All Tags, HisAll Species, HumanCSP-24016Show detailsall-tags hisall-species human
TROP-2All Tags, Flag-HisAll Species, HumanCSP-24041-02Show detailsall-tags flag-hisall-species human
CD2All Tags, His-AviAll Species, HumanCSP-24095-03Show detailsall-tags his-aviall-species human
CD38All Tags, His-AviAll Species, HumanCSP-24096-03Show detailsall-tags his-aviall-species human
B7H3 isoform 2lgAll Tags, His-AviAll Species, HumanCSP-240982lgShow detailsall-tags his-aviall-species human
B7H3 isoform 4lgAll Tags, His-AviAll Species, HumanCSP-240984lgShow detailsall-tags his-aviall-species human
CD117All Tags, His-AviAll Species, HumanCSP-24123-03Show detailsall-tags his-aviall-species human
TROP-2All Tags, Flag-HisAll Species, MouseCSP-25191-02Show detailsall-tags flag-hisall-species mouse
CD117All Tags, His-AviAll Species, MouseCSP-25193-03Show detailsall-tags his-aviall-species mouse
CD117All Tags, His-AviAll Species, Rhesus MacaqueCSP-25194-03Show detailsall-tags his-aviall-species rhesus-macaque
Nectin-1All Tags, His-AviAll Species, HumanCSP-25195-03Show detailsall-tags his-aviall-species human
Nectin-3All Tags, His-AviAll Species, HumanCSP-25196-03Show detailsall-tags his-aviall-species human
PVRAll Tags, HisAll Species, Rhesus MacaqueCSP-25297-01Show detailsall-tags hisall-species rhesus-macaque

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We offer a wide range of recombinant conformational proteins and antibodies, and our catalog is rapidly growing. If you don’t see what you need or have a custom project in mind, send us a request!
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Spotlight: Nectin-4

Nectin-4 model prediction
Bioactive Performance Nectin-4 is a tumor-associated antigen involved in cell adhesion and immune modulation. Conigen’s Nectin-4 protein dimer mimics its native dimer configuration and shows enhanced binding to the TIGIT protein dimer compared to monomeric forms.

Human Nectin-4 protein dimer, His-Tag (CSP-24016) or Nectin-4 protein monomer binding to TIGIT protein dimer, Fc-Tag (TIGIT-Fc, CSP-24028) as measured by ELISA. Nectin-4 protein dimer significantly enhances the binding to TIGIT compared to Nectin-4 monomer. The Nectin-4 protein dimer or monomer (0.2 μg/ml) was coated on 96-well microtiter plates and detected by serial dilutions of TIGIT-Fc.

These recombinant proteins are ideal for studying receptor-ligand dynamics, therapeutic antibody development, and cancer biology research.