Overview
Understanding cytokine-receptor interactions is critical for advancing immunology research and therapeutic development, but capturing these interactions in a native-like state can be challenging.
In this webinar, Conigen Bioscience’s Assay Development Scientist, Dr. Alyssa Ball will shares how they leveraged Nicoya’s Alto digital surface plasmon resonance (SPR) system to characterize the binding kinetics of several homo- and heterodimeric cytokine receptors, including human Type II interferon γ receptor 1 (IFNγR1) and human Type I interferon α receptor (IFNαR).
Topics covered in this webinar:
- How Conigen Bioscience’s innovative soluble protein dimers enhance ligand binding sensitivity and potency of cytokine receptor proteins
- Why SPR was critical for revealing nuanced differences in binding potency
- How Alto digital SPR enables rapid, high-quality kinetic data for complex receptor-ligand systems
- How real-time, label-free kinetic analysis combined with structural and stability characterization can accelerate the selection of functionally relevant and stable therapeutic candidates
Whether you’re working in basic immunology or drug discovery, this webinar will showcase how these innovative soluble cis-dimer proteins can significantly enhance binding potency and enable more accurate characterization of complex protein interactions.
