Immobilized human MAS1 fragment at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human MAS1 Monoclonal Antibody (Cat. No. CABh-25325) with half maximal effective concentration (EC50) range of 4.3-17 ng/mL (QC tested).
Detection of MAS1 in HEK293 human cell line transiently transfected with human MAS1 by Flow Cytometry. HEK293 cell line transfected with human MAS1 was stained with isotype control (black curve) or Mouse Anti-Human MAS1 Monoclonal Antibody (Cat. No. CABh-25325) (green curve) by APC-conjugated Anti-Mouse IgG Secondary Antibody.

Anti-Human MAS1 Monoclonal Antibody

Product Category: All Products

Product Code: CABh-25325
Isotype: IgG2a
Specificity: Detects human MAS1 proto-oncogene/MAS1 transfectants but not irrelevant transfectants in flow cytometry.
Host Species: Mouse
Immunogen: MAS1 N-terminus extracellular domain, the exact sequence of the immunogen is proprietary.; UniProt # P04201
Purification: Affinity Enrichment
Expression Host: HEK293T
Verified Applications: ELISA, Flow cytometry
Recommended Usage: ELISA: starting concentration 1 µg/mL Flow cytometry: 0.8 µg/1E6 cells

For Research Use Only (RUO)

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Formulation: 0.22μm filtered PBS, pH 7.4
Shipping: Frozen Dry Ice
Storage: -80’C

Datasheet

MSDS

Structure: 7-transmembrane protein, G protein-coupled receptor (GPCR)
Function: Key role in the renin–angiotensin system (RAS)
Ligand/Receptor: Angiotensin-(1–7)
Cell Type: Wide distribution, especially Cardiovascular and Nervous systems
Molecular Family: G protein-coupled receptor
Gene ID: P04201
Product Name: MAS1, Monoclonal Antibody
UniProt #: P04201
Predicted Molecular Weight: N/A
Protein Construct: N/A

Background and Alternate Names

Human MAS1 proto-oncogene (MAS1), is a 7-transmembrane G protein-coupled receptor (GPCR). MAS1 is a Class A GPCR. Angiotensin-(1–7) is the ligand for MAS1 and MAS1 plays a key role in the renin–angiotensin system (RAS), which regulates blood pressure, fluid balance, and cardiovascular function. Unlike classical angiotensin receptors such as AT1 and AT2, MAS1 is considered part of the protective arm of the RAS. Therapeutic potential of MAS1 receptor has gained increasing attention and is being explored as a target for treating hypertension, heart failure, and even complications related to metabolic and pulmonary diseases. Additionally, MAS1 has been studied in the context of COVID-19, as it interacts with ACE2-related pathways. Human MAS1 protein has 85-90% sequence homology with mouse MAS1.

Alternate Names: MAS proto-oncogene, MAS, MGRA