Conigen Bioscience provides novel bioactive membrane proteins as tool molecules for research and drug discovery.
Our current portfolio includes soluble cis-dimer recombinant proteins and multi-pass membrane proteins, along with custom protein design and expression services.
This video highlights soluble homodimer and heterodimer proteins, available across a variety of categories including Immune Checkpoints, Tumor-Associated Antigens, and Cytokine Receptors.
Expressed in mammalian cells using Conigen proprietary CSP™ technology, these recombinant proteins present the ectocellular domains of Type 1 membrane proteins.
We performed structural modeling on multiple homo and heterodimer molecules with results matching to experimental crystal structures.
Conigen dimers exhibit significantly higher receptor/ligand binding compared to monomers.
They can be used as immunogens with no glycosylation and immune silence in mice, enabling antibody generation focused on the target molecules.
They can also be used as antigens for B cell sorting, antibody screening and characterization providing a larger assay window.
Whether you need soluble cis-dimer recombinant proteins, multi-pass membrane proteins, or custom mammalian cell expression of recombinant proteins, including recombinant antibodies, contact Conigen to discuss your next project.
